Ben and Chon are charismatic pot growers who live peacefully on the outskirts of Los Angeles. Their seemingly ideal existence hits a snag when their shared girlfriend, O, disappears mysteriously. Suspecting foul play, the pair venture into the city to investigate her whereabouts, where they quickly find themselves pitted against a gang of vicious drug dealers from a Mexican cartel. Will a surprising new ally be able to help our stoners defeat the cartel and save their lady?