After reuniting with their adopted daughters Margo, Edith, and Agnes and welcoming newborn Gru Jr., Gru and Lucy face a new challenge when enemy number one, Maxime Le Mal, threatens to expose Gru's secret identity as a villain. With the help of new nemesis Valentina and an unpredictable partner in crime, the cunning and greedy Maxime, Gru, and the family go on the run to save their reputation and hide their identities